hereditary spastic paraplegia 10 (MONDO_0011408) can be described as follows. Autosomal dominant spastic paraplegia type 10 (SPG10) is a rare type of hereditary spastic paraplegia that can present as either a pure form of spastic paraplegia with lower limb spasticity, hyperreflexia and extensor plantar responses, presenting in childhood or adolescence, or as a complex phenotype associated with additional manifestations including peripheral neuropathy with upper limb amyotrophy, moderate intellectual disability and parkinsonism. Deafness and retinitis pigmentosa were reported in one case. Also known as: KIF5A hereditary spastic paraplegia, SPG10, autosomal dominant spastic paraplegia 10, autosomal dominant spastic paraplegia type 10, hereditary spastic paraplegia caused by mutation in KIF5A, hereditary spastic paraplegia type 10.