hereditary spastic paraplegia 12 (Monarch Disease Ontology id MONDO_0011489) can be described as follows. Autosomal dominant spastic paraplegia type 12 is a pure form of hereditary spastic paraplegia characterized by a childhood- to adulthood-onset of slowly progressive lower limb spasticity and hyperreflexia of lower extremities, extensor plantar reflexes, distal sensory impairment, variable urinary dysfunction and pes cavus. Also known as: RTN2 hereditary spastic paraplegia, SPG12, autosomal dominant spastic paraplegia 12, autosomal dominant spastic paraplegia type 12, hereditary spastic paraplegia caused by mutation in RTN2, hereditary spastic paraplegia type 12.