Brooke-Spiegler syndrome (Monarch Disease Ontology entry MONDO_0011512) (BSS) is an inherited predisposition syndrome presenting with skin appendage tumors, namely cylindromas, spiradenomas and trichoepitheliomas. A minority of patients can also get major and minor salivary glands neoplasms, usually membranous basal cell adenoma. Also known as: CYLD cutaneous syndrome.