pseudohyperaldosteronism type 2 (Monarch Disease Ontology term MONDO_0011517) can be described as follows. Hypertension due to gain-of-function mutations in the mineralocorticoid receptor is a rare genetic hypertension characterized by a familial severe hypertension with an onset before age 20 years, associated with suppressed plasma renin and low aldosterone levels in the presence of low or normal levels of the mineralocorticoid aldosterone, that is highly resistant to antihypertensive medication. During pregnancy, there is a marked exacerbation of hypertension, accompanied by low serum potassium levels and undetectable aldosterone levels, but without signs of preeclampsia, requiring early delivery. Also known as: early-onset hypertension with exacerbation in pregnancy, hypertension due to gain-of-function mutations in the mineralocorticoid receptor, hypertension, early-onset, autosomal dominant, with exacerbation in pregnancy.