Neonatal ichthyosis-sclerosing cholangitis (NISCH syndrome) is a very rare complex ichthyosis syndrome characterized by scalp hypotrichosis, scarring alopecia, ichthyosis and sclerosing cholangitis. The disease is neonatal ichthyosis-sclerosing cholangitis syndrome (MONDO_0011874, a Monarch Disease Ontology identifier). Also known as: IHSC, NISCH syndrome, ichthyosis-hypotrichosis-sclerosing cholangitis syndrome.