Autosomal dominant osteopetrosis type I (ADO I) is a sclerosing bone disorder characterized by skeletal densification that predominantly involves the cranial vault. The disease is autosomal dominant osteopetrosis 1 (MONDO_0011877, a Monarch Disease Ontology entry). Also known as: LRP5 osteopetrosis (disease), OPTA1, autosomal dominant osteopetrosis type 1, osteopetrosis (disease) caused by mutation in LRP5, osteopetrosis, autosomal dominant type 1.