An immunodeficiency associated with increased susceptibility to invasive infections caused by pyogenic bacteria. The disease is MONDO_0011888 (immunodeficiency 67). Also known as: IRAK4 deficiency, immunodeficiency due to interleukin-1 receptor-associated kinase-4 deficiency, invasive pneumococcal disease, recurrent isolated, 1, invasive pneumococcal disease, recurrent isolated, type 1.