A form of CMT1, with a variable clinical presentation that can range from severe impairment with onset in childhood to mild impairment appearing during adulthood. CMT1F is characterized by a progressive peripheral motor and sensory neuropathy with distal paresis in the lower limbs that varies from mild weakness to complete paralysis of the distal muscle groups, absent tendon reflexes and reduced nerve conduction. CMT1F represents the ''demyelinating'' form of CMT2E and is caused by mutations in the NEFL gene (8p21.2).. The disease is Monarch Disease Ontology id MONDO_0011902 (Charcot-Marie-Tooth disease type 1F). Also known as: CMT1F, Charcot-Marie-Tooth disease type 1 caused by mutation in NEFL, Charcot-Marie-Tooth disease, type 1F, Charcot-Marie-Tooth neuropathy type 1F, NEFL Charcot-Marie-Tooth disease type 1.