Dermatofibrosarcoma protuberans (DFSP) is a rare infiltrating soft tissue sarcoma, generally of low grade malignancy, arising from the dermis of the skin and characteristically associated with a specific chromosomal translocation t(17;22). The disease is dermatofibrosarcoma protuberans (MONDO_0011934, a Monarch Disease Ontology id). Also known as: DFSP, dermatofibrosarcoma.