Familial acute necrotizing encephalopathy or ADANE is a potentially fatal neurological disease characterized by neuropathological lesions principally involving the brainstem, thalamus and putamen. The disease is MONDO_0011953 (familial acute necrotizing encephalopathy). Also known as: ADANE, encephalopathy, acute, infection-induced, 3, susceptibility to, encephalopathy, acute, infection-induced, susceptibility to, type 3, recurrent acute necrotizing encephalopathy.