A severe combined immunodeficiency characterized by being T cell-negative, B cell-positive and natural killer cell-positive and that has material basis in homozygous or compound heterozygous mutation in the IL7R gene on chromosome 5p13 or the CD45 gene on chromosome 1q31. The disease is immunodeficiency 104 (Monarch Disease Ontology entry MONDO_0012163). Also known as: IMD104, autosomal recessive T cell-negative, B-cell negative, NK cell-positive SCID, autosomal recessive T cell-negative, B-cell positive, NK cell-positive SCID, severe combined immunodeficiency, T cell-negative, B-cell/natural killer-cell positive, severe combined immunodeficiency, T-cell negative, B-cell/natural killer cell-positive type, severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-positive, NK cell-positive.