Talo-patello-scaphoid osteolysis is an extremely rare form of primary osteolysis, described in two sisters to date, characterized by bilateral osteolysis of the tali, scaphoids, and patellae (accompanied by periarticular swelling and pain) and short fourth metacarpals (brachydactyly type E), in the absence of renal disease. Autosomal recessive inheritance has been suggested. The disease is talo-patello-scaphoid osteolysis (Monarch Disease Ontology identifier MONDO_0012330). Also known as: singh-Williams-McAlister syndrome.