Mandibulofacial dysostosis-microcephaly syndrome is a rare genetic multiple malformation disorder characterized by malar and mandibular hypoplasia, microcephaly, ear malformations with associated conductive hearing loss, distinctive facial dysmorphism, developmental delay, and intellectual disability. The disease is mandibulofacial dysostosis-microcephaly syndrome (Monarch Disease Ontology identifier MONDO_0012516). Also known as: MFDM syndrome, mandibulofacial dysostosis with microcephaly, mandibulofacial dysostosis, Guion-Almeida type.