Type A insulin-resistance syndrome belongs to the group of extreme insulin-resistance syndromes (which includes leprechaunism, the lipodystrophies, Rabson-Mendenhall syndrome and type B insulin resistance syndrome) and is characterized by the triad of hyperinsulinemia, acanthosis nigricans (skin lesions associated with insulin resistance), and signs of hyperandrogenism in females without lipodystrophy and who are not overweight. The disease is Monarch Disease Ontology entry MONDO_0012520 (insulin-resistance syndrome type A). Also known as: insulin resistant diabetes mellitus with acanthosis nigricans and hyperandrogenism, type A insulin resistance syndrome.