Any COFS syndrome in which the cause of the disease is a mutation in the ERCC2 gene. The disease is cerebrooculofacioskeletal syndrome 2 (MONDO_0012553, a Monarch Disease Ontology id). Also known as: COFS syndrome caused by mutation in ERCC2, COFS2, ERCC2 COFS syndrome, cerebrooculofacioskeletal syndrome type 2.