XFE progeroid syndrome (MONDO_0012590) is a syndrome characterized by aged bird-like facies, lack of subcutaneous fat, dwarfism, cachexia and microcephaly. Additional features include sun-sensitivity from birth, learning disabilities, hearing loss, and visual impairment. It has material basis in homozygous mutation in the ERCC4 gene on chromosome 16p13. Also known as: XFEPS, XPF-ERCC1 progeroid syndrome.