Any isolated microphthalmia in which the cause of the disease is a mutation in the MFRP gene. The disease is isolated microphthalmia 5 (MONDO_0012605, a Monarch Disease Ontology term). Also known as: MCOP5, MFRP isolated microphthalmia, Nanophtalmos-retinitis pigmentosa-foveoschisis-optic disc drusen syndrome, Nanophtalmos-retinitis pigmentosa-foveoschisis-optic disk drusen syndrome, isolated microphthalmia caused by mutation in MFRP, isolated microphthalmia type 5, microphthalmia, isolated type 5, microphthalmia-retinitis pigmentosa-foveoschisis-optic disc drusen syndrome.