Monarch Disease Ontology term MONDO_0012611 (polyhydramnios, megalencephaly, and symptomatic epilepsy) is a syndrome characterized by polyhydramnios, distinctive craniofacial features, infantile-onset epilepsy, hypotonia, macrocephaly, and global developmental delay that has material basis in homozygous mutation in the STRADA gene on chromosome 17q23.3. Also known as: PMSE syndrome.