Any hereditary predisposition to infections in which the cause of the disease is a mutation in the TYK2 gene. The disease is immunodeficiency 35 (MONDO_0012682). Also known as: HIES with atypical Mycobacteriosis, autosomal recessive, IMD35, TYK2 autosomal recessive mendelian susceptibility to mycobacterial diseases due to a partial deficiency, TYK2 deficiency, autosomal recessive hyper-IgE syndrome due to TYK2 deficiency, autosomal recessive mendelian susceptibility to mycobacterial diseases due to a partial deficiency caused by mutation in TYK2, hyper-IgE syndrome with atypical Mycobacteriosis, autosomal recessive, immunodeficiency type 35.