Coats plus syndrome is a pleiotropic multisystem disorder characterized by retinal telangiectasia and exudates, intracranial calcification with leukoencephalopathy and brain cysts, osteopenia with predisposition to fractures, bone marrow suppression, gastrointestinal bleeding and portal hypertension. It is transmitted as an autosomal recessive disease. The disease is MONDO_0012815 (Coats plus syndrome). Also known as: CRMCC, cerebroretinal microangiopathy with calcfications and cysts, cerebroretinal microangiopathy with calcifications and cysts.