Crouzon syndrome-acanthosis nigricans syndrome (MONDO_0012833) can be described as follows. Crouzon syndrome with acanthosis nigricans (CAN) is a very rare, clinically heterogeneous form of faciocraniostenosis with Crouzon-like features and premature synostosis of cranial sutures (Crouzon disease), associated with acanthosis nigricans (AN). Also known as: CAN, Chronic kidney allograft nephropathy, Crouzon-dermoskeletal syndrome, Crouzonodermoskeletal syndrome, chronic allograft nephropathy.