hereditary spastic paraplegia 35 (MONDO_0012866) can be described as follows. Autosomal recessive spastic paraplegia type 35 is a rare form of hereditary spastic paraplegia characterized by childhood (exceptionally adolescent) onset of a complex phenotype presenting with lower limb (followed by upper limb) spasticity with hyperreflexia and extensor plantar responses, with additional manifestations including progressive dysarthria, dystonia, mild cognitive decline, extrapyramidal features, optic atrophy and seizures. White matter abnormalities and brain iron accumulation have also been observed on brain magnetic resonance imaging. Also known as: FA2H hereditary spastic paraplegia, SPG35, autosomal recessive spastic paraplegia 35, autosomal recessive spastic paraplegia type 35, hereditary spastic paraplegia caused by mutation in FA2H, hereditary spastic paraplegia type 35, leukodystrophy, dysmyelinating and spastic paraparesis with or without dystonia.