Hemolytic anemia due to adenylate kinase deficiency is a rare hemolytic anemia due to an erythrocyte nucleotide metabolism disorder characterized by moderate to severe chronic nonspherocytic hemolytic anemia that may require regular blood transfusions and/or splenectomy and may be associated with psychomotor impairment. The disease is hemolytic anemia due to adenylate kinase deficiency (MONDO_0012967, a Monarch Disease Ontology entry). Also known as: adenylate kinase deficiency, hemolytic anaemia due to, adenylate kinase deficiency, hemolytic anemia due to.