Any striate palmoplantar keratoderma in which the cause of the disease is a mutation in the DSP gene. The disease is keratosis palmoplantaris striata 2 (MONDO_0013034, a Monarch Disease Ontology id). Also known as: DSP striate palmoplantar keratoderma, keratosis palmoplantaris striata type 2, striate palmoplantar keratoderma caused by mutation in DSP.