Congenital hypopituitarism is characterized by multiple pituitary hormone deficiency, including somatotroph, thyrotroph, lactotroph, corticotroph or gonadotroph deficiencies, due to mutations of pituitary transcription factors involved in pituitary ontogenesis. Congenital hypopituitarism is rare compared with the high incidence of hypopituitarism induced by pituitary adenomas, transsphenoidal surgery or radiotherapy. The disease is MONDO_0013099 (combined pituitary hormone deficiencies, genetic form). Also known as: familial congenital hypopituitarism, genetic hypopituitarism, multiple pituitary hormone deficiencies, genetic forms, pituitary hormone deficiency, combined.