Autosomal recessive limb-girdle muscular dystrophy type 2O (LGMD2O) is a form of limb-girdle muscular dystrophy characterized by an onset in childhood or adolescence of rapidly progressive proximal limb muscle weakness (particularly affecting the neck, hip girdle, and shoulder abductors), hypertrophy in the calves and quadriceps, ankle contractures, and myopia. The disease is autosomal recessive limb-girdle muscular dystrophy type 2O (MONDO_0013161, a Monarch Disease Ontology term). Also known as: LGMD-POMGNT1 related, LGMD2O, MDDGC3, POMGNT1 autosomal recessive limb-girdle muscular dystrophy, autosomal recessive limb-girdle muscular dystrophy caused by mutation in POMGNT1, muscular dystrophy-dystroglycanopathy (limb-girdle) type C3, muscular dystrophy-dystroglycanopathy limb-girdle POMGNT1-related.