Autosomal recessive spastic paraplegia type 45 is a rare, pure or complex form of hereditary spastic paraplegia characterized by onset in infancy of progressive lower limb spasticity, abnormal gait, increased deep tendon reflexes and extensor plantar responses, that may be associated with intellectual disability. Additional signs, such as contractures in the lower limbs, amyotrophy, clubfoot and optic atrophy, have also been reported. The disease is MONDO_0013165 (hereditary spastic paraplegia 45). Also known as: NT5C2 autosomal recessive complex spastic paraplegia, SPG45, SPG65, autosomal recessive complex spastic paraplegia caused by mutation in NT5C2, autosomal recessive spastic paraplegia 45, autosomal recessive spastic paraplegia type 45, autosomal recessive spastic paraplegia type 65, hereditary spastic paraplegia type 45.