Monarch Disease Ontology id MONDO_0013179 (hereditary spastic paraplegia 44) is a very rare, complex form of hereditary spastic paraplegia characterized by a late-onset, slowly progressive spastic paraplegia associated with mild ataxia and dysarthria, upper extremity involvement (i.e. loss of finger dexterity, dysmetria), and mild cognitive impairment, without the presence of nystagmus. A hypomyelinating leukodystrophy and thin corpus callosum is observed in all cases and psychomotor development is normal or near normal. SPG44 is caused by mutations in the GJC2 gene (1q41-q42) encoding the gap junction gamma-2 protein. Also known as: GJC2 autosomal recessive complex spastic paraplegia, SPG44, autosomal recessive complex spastic paraplegia caused by mutation in GJC2, autosomal recessive spastic paraplegia 44, hereditary spastic paraplegia type 44.