An autosomal dominant syndrome caused by pathogenic variants in the TSC2 gene, characterized by the growth of hamartomas in multiple organs, including the brain, skin, kidneys, heart, and lungs. Other clinical features include seizures, intellectual disability, and skin lesions. The disease is Monarch Disease Ontology id MONDO_0013199 (tuberous sclerosis 2). Also known as: TSC2-related tuberous sclerosis, tuberous sclerosis type 2, tuberous sclerosis-2.