Autosomal dominant spastic paraplegia type 41 is a pure form of hereditary spastic paraplegia characterized by onset in adolescence or early adulthood of slowly progressive spastic paraplegia, proximal muscle weakness of the lower extremities and small hand muscles, hyperreflexia, spastic gait and mild urinary compromise. The disease is MONDO_0013239 (hereditary spastic paraplegia 41). Also known as: SPG41, autosomal dominant spastic paraplegia 41, autosomal dominant spastic paraplegia type 41, hereditary spastic paraplegia type 41.