Any familial isolated dilated cardiomyopathy in which the cause of the disease is a mutation in the PSEN1 gene. The disease is Monarch Disease Ontology identifier MONDO_0013371 (dilated cardiomyopathy 1U). Also known as: CMD1U, PSEN1 familial isolated dilated cardiomyopathy, cardiomyopathy, dilated, type 1U, dilated cardiomyopathy type 1U, familial isolated dilated cardiomyopathy caused by mutation in PSEN1.