Any familial isolated dilated cardiomyopathy in which the cause of the disease is a mutation in the PSEN2 gene. The disease is dilated cardiomyopathy 1V (Monarch Disease Ontology id MONDO_0013373). Also known as: CMD1V, PSEN2 familial isolated dilated cardiomyopathy, cardiomyopathy, dilated, type 1V, dilated cardiomyopathy type 1V, familial isolated dilated cardiomyopathy caused by mutation in PSEN2.