Monarch Disease Ontology entry MONDO_0013453 (Leber congenital amaurosis 8) is any Leber congenital amaurosis in which the cause of the disease is a mutation in the CRB1 gene. Also known as: CRB1 Leber congenital amaurosis, LCA8, Leber congenital amaurosis caused by mutation in CRB1, Leber congenital amaurosis type 8.