Familial progressive hyperpigmentation is a rare, genetic, skin pigmentation anomaly disorder characterized by irregular patches of hyperpigmented skin which present at birth or in early infancy and increase in size, number and confluence with age. Affected areas of the body include the face, neck, trunk and limbs, as well as the palms, soles, oral mucosa and conjuctiva. No hypogmentation macules are observed and no systemic diseases are associated. The disease is Monarch Disease Ontology identifier MONDO_0013648 (familial progressive hyperpigmentation). Also known as: melanosis diffusa congenita, melanosis universalis hereditaria, universal melanosis.