A rare, complex type of hereditary spastic paraplegia characterized by an onset, in infancy or childhood, of the typical signs of spastic paraplegia (i.e. spastic gait and weakness of the lower limbs) associated with a variety of additional manifestations including upper limb spasticity and weakness, pseudobulbar dysarthria, bladder dysfunction, cerebellar ataxia, cataracts, and cognitive impairment that can progress to dementia. Brain imaging may show thinning of the corpus callosum and mild atrophy of the cerebrum and cerebellum. SPG46 is due to mutations in the GBA2 gene (9p13.2) encoding non-lysosomal glucosylceramidase. The disease is MONDO_0013737 (hereditary spastic paraplegia 46). Also known as: GBA2 autosomal recessive complex spastic paraplegia, SPG46, autosomal recessive complex spastic paraplegia caused by mutation in GBA2, autosomal recessive spastic paraplegia 46, autosomal recessive spastic paraplegia type 46, hereditary spastic paraplegia type 46.