Monarch Disease Ontology id MONDO_0013759 (melanoma, cutaneous malignant, susceptibility to, 8) is an inherited cancer-predisposing syndrome due to a gain-of-function germline mutation in the MITF gene, associated with a higher incidence of amelanotic and nodular melanoma, multiple primary melanomas and increase in nevus number and size. It may also predispose to co-occurring melanoma and renal cell carcinoma and to pancreatic cancer. Also known as: MITF-related melanoma and renal cell carcinoma predisposition syndrome, melanoma, cutaneous malignant, susceptibility to, type 8.