Any meconium ileus in which the cause of the disease is a mutation in the GUCY2C gene. The disease is intestinal obstruction in the newborn due to guanylate cyclase 2C deficiency (MONDO_0013843, a Monarch Disease Ontology term). Also known as: GUCY2C meconium ileus, meconium ileus caused by mutation in GUCY2C, meconium ileus due to guanylate cyclase 2C deficiency.