Any peroxisome biogenesis disorder due to PEX6 defect characterized by the association of early-onset cerebellar ataxia with hearing loss and blindness. Patients may also present demyelinating peripheral motor neuropathy. Cerebral MRI shows alterations of the cerebellar white matter without cerebellar atrophy. The disease is Monarch Disease Ontology term MONDO_0013931 (peroxisome biogenesis disorder 4B). Also known as: PBD4B, SCABD, SCAR3, autosomal recessive cerebellar ataxia-blindness-deafness syndrome, autosomal recessive spinocerebellar ataxia type 3, autosomal recessive spinocerebellar ataxia-blindness-hearing loss syndrome, peroxisome biogenesis disorder type 4B, spinocerebellar ataxia autosomal recessive 3.