Charcot-Marie-Tooth disease type 4F (MONDO_0013959) (CMT4F) is a severe, demyelinating subtype of Charcot-Marie-Tooth disease type 4 characterized by the childhood onset of a slowly-progressing typical CMT phenotype (i.e. distal muscle weakness and atrophy, as well as pes cavus) that presents severe sensory loss (frequently with sensory ataxia), moderately to severely reduced motor nerve conduction velocities and almost invariable absence of sensory nerve action potentials, and delayed motor milestones. Also known as: CMT4F, Charcot-Marie-Tooth disease type 4 caused by mutation in PRX, Charcot-Marie-Tooth disease type 4 caused by mutation in Prx, Charcot-Marie-Tooth disease, type 4F, PRX Charcot-Marie-Tooth disease type 4, Prx Charcot-Marie-Tooth disease type 4.