Any congenital hydrocephalus in which the cause of the disease is a mutation in the MPDZ gene. The disease is Monarch Disease Ontology id MONDO_0014085 (hydrocephalus, nonsyndromic, autosomal recessive 2). Also known as: MPDZ congenital hydrocephalus, congenital hydrocephalus caused by mutation in MPDZ, hydrocephalus, congenital, 2, with or without brain or eye anomalies, hydrocephalus, nonsyndromic, autosomal recessive type 2.