mitochondrial DNA depletion syndrome 13 (MONDO_0014198) is any mitochondrial DNA depletion syndrome in which the cause of the disease is a mutation in the FBXL4 gene. Also known as: FBXL4 mitochondrial DNA depletion syndrome, mitochondrial DNA depletion syndrome caused by mutation in FBXL4, mitochondrial DNA depletion syndrome type 13, mtDNA depletion syndrome, encephalomyopathic form with variable craniofacial anomalies.