triosephosphate isomerase deficiency (MONDO_0014221) can be described as follows. Triosephosphate isomerase (TPI) deficiency is a severe autosomal recessive inherited multisystem disorder of glycolytic metabolism characterized by hemolytic anemia and neurodegeneration. Also known as: hemolytic anaemia due to triosephosphate isomerase deficiency, hemolytic anemia due to triosephosphate isomerase deficiency, triose phosphate-isomerase deficiency.