Any severe combined immunodeficiency in which the cause of the disease is a mutation in the CD3D gene. The disease is Monarch Disease Ontology identifier MONDO_0014280 (immunodeficiency 19). Also known as: CD3D, CD3D severe combined immunodeficiency (disease), CD3delta deficiency, immunodeficiency type 19, severe combined immunodeficiency (disease) caused by mutation in CD3D.