An extremely rare and complex form of hereditary spastic paraplegia characterized by an onset in infancy of spastic paraplegia (presenting with delayed walking and a scissors gait) associated with short stature, and normal cognition. Periventricular deep white matter changes in the corpus callosum are noted on brain imaging. SPG63 is caused by a homozygous mutation in the AMPD2 gene (1p13.3) encoding AMP deaminase 2. The disease is hereditary spastic paraplegia 63 (MONDO_0014305). Also known as: AMPD2 autosomal recessive complex spastic paraplegia, SPG63, autosomal recessive complex spastic paraplegia caused by mutation in AMPD2, autosomal recessive spastic paraplegia 63, hereditary spastic paraplegia type 63, spastic paraplegia 63.