deficiency of adenosine deaminase 2 (MONDO_0014306, a Monarch Disease Ontology id) is a rare autoinflammatory disease characterized by a broad clinical phenotype of systemic inflammation, vasculitis, early-onset stroke, immunodeficiency and bone marrow failure. The disease typically presents in young children, although adult cases are being discovered. Also known as: ADA2 deficiency, DADA2, adenosine deaminase 2 deficiency, childhood-onset polyarteritis nodosa, polyarteritis nodosa, childhood-onset, vasculitis, autoinflammation, immunodeficiency, and hematologic defects syndrome.