Any hereditary cancer predisposition due to variation(s) in the POT1 gene, which confers a predisposition to development of various types of benign and malignant neoplasms. The disease is tumor predisposition syndrome 3 (MONDO_0014368). Also known as: CMM10, GLM9, POT1 tumor predisposition, POT1-TPD, POT1-related tumor predisposition syndrome, glioma susceptibility 9, glioma susceptibility type 9, malignant glioma caused by mutation in POT1.