Any non-syndromic pontocerebellar hypoplasia in which the cause of the disease is a mutation in the VPS53 gene. The disease is MONDO_0014370 (pontocerebellar hypoplasia type 2E). Also known as: VPS53 non-syndromic pontocerebellar hypoplasia, non-syndromic pontocerebellar hypoplasia caused by mutation in VPS53.