Bleeding disorder due to CalDAG-GEFI deficiency is a rare hematologic disease due to defective platelet function and characterized by mucocutaneous bleeding starting in infancy (around 18 months of age), presenting with prolonged and severe epistaxis, hematomas and bleeding after tooth extraction. Massive menorrhagia and chronic anemia have also been reported. The disease is MONDO_0014386 (platelet-type bleeding disorder 18). Also known as: BDPLT18, RASGRP2 inherited bleeding disorder, platelet-type, bleeding disorder due to CalDAG-GEFI deficiency, bleeding disorder due to calcium- and DAG-regulated guanine exchange factor-1 deficiency, inherited bleeding disorder, platelet-type caused by mutation in RASGRP2.