Any combined oxidative phosphorylation deficiency in which the cause of the disease is a mutation in the VARS2 gene. The disease is Monarch Disease Ontology identifier MONDO_0014397 (combined oxidative phosphorylation defect type 20). Also known as: COXPD20, VARS2 combined oxidative phosphorylation deficiency, combined oxidative phosphorylation deficiency caused by mutation in VARS2, combined oxidative phosphorylation deficiency type 20.