severe combined immunodeficiency due to DNA-PKcs deficiency (MONDO_0014423) can be described as follows. Severe combined immunodeficiency (SCID) due to DNA-PKcs deficiency is an extremely rare type of SCID characterized by the classical signs of SCID (severe and recurrent infections, diarrhea, failure to thrive), absence of T and B lymphocytes, and cell sensitivity to ionizing radiation. Also known as: SCID due to DNA-PKcs deficiency, immunodeficiency 26, with or without neurologic abnormalities.